Mary Cushman, M.D.

Professor of Medicine

Research Program: Clinical Research
VCC Membership Level: Full Member

Contact Information

Department of Medicine
208 South Park Drive, Suite 2
University of Vermont
Colchester, VT 05446

ph: (802) 656-8968
f: (802) 656-8965
Mary.Cushman@uvm.edu

Biography

Dr. Cushman is a member of the Division of Hematology/Oncology of the Department of Medicine at Fletcher Allen Health Care. She is the recipient of a Clinical Scientist Development Award from the National Heart, Lung, and Blood Institute (NHLBI). She was an Honored Speaker at the NHLBI 50th Anniversary Celebration Fall Advisory Council. Dr. Cushman is on the Leadership Committee and is the Program Chair for the the Spring Scientific Conference of the American Heart Association's Council on Epidemiology and Prevention.

Recent Publications

Johnson JV, Lowell J, Badger GJ, Rosing J, Tchaikovski S, Cushman M. Effects of oral and transdermal contraception on vascular risk markers. Obstet Gynecol 2008;111:278-84.

Glasser CP, Cushman M, Prineas R, Kleindorfer D, Prince V, You Z, Howard VJ, Howard G. Does differential prophylactic aspirin use contribute to racial and geographic disparities in stroke and coronary heart disease? Prev Med 2008;47:161-6.

Ankle-Brachial Index Collaboration. Ankle brachial index combined with Framingham risk score to predict cardiovascular events and mortality: a meta-analysis. JAMA 2008;300:197-208.

Voeks JH, McClure LA, Go RC, Prineas RJ, Cushman M, Kissela BM, Roseman JM. Regional differences in diabetes as a possible contributor to the geographic disparity in stroke mortality: The REasons for Geographic And Racial Differences in Stroke Study. Stroke 2008;39:1675-80

Zakai NA, Ohira T, White R, Folsom AR, Cushman M. Prospective study of the activated partial thromboplastin time and risk of incident venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology. Am J Med 2008;121:231-8

Cushman M, Epidemiology and risk factors for venous thrombosis. Semin Hematol. 2007;44:62-9.

Kooperberg C, Cushman M, Hsia J, Robinson JG, Aragaki AK, Lynch JK, Baird AE, Johnson KC, Kuller LH, Beresford SA, Rodriguez B. Can biomarkers identify women at increased stroke risk? The Women's Health Initiative hormone trials. PLoS Clin Trials 2007;15:e28.

Cao JJ, Arnold AM, Manolio TA, Psaty BM, Hirsch CH, Polak JF, Kuller LH, Cushman M. Association of carotid artery intima-media thickness, plaques and C-reactive protein with future cardiovascular disease and all-cause mortality: the Cardiovascular Health Study. Circulation 2007;116:32-8.

Zakai N, Jenny NS, Tracy RP, Reiner AP, Psaty BM, Schwartz S, Cushman M. Comparison of multiple inflammatory markers in the prediction of cardiovascular disease in older men and women. J Thromb Haemost 2007;5:1128-35.

Kronmal RA, McClelland RL, Detrano R, Shea S, Lima JA, Burke G, Bild DE, Cushman M. Risk factors for progression of coronary artery calcification in asymptomatic subjects: results from the Multi-ethnic Study of Atherosclerosis (MESA). Circulation 2007;115:2722-30.

Steffen LM, Folsom AR, Cushman M, Jacobs DR Jr, Rosamond W. Greater fish, fruit and vegetable intakes are related to lower incidence of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology. Circulation 2007;115:188-95.

Cushman M, Glynn R, Goldhaber SZ, Moll S, Bauer KA, Deitcher S, Shrivastava S, Ridker PM. Hormonal factors and risk of recurrent venous thrombosis: the Prevention of Recurrent Venous Thromboembolism Trial. J Thromb Haemost 2006;4:2199-2203.

Lange L, Carlson CS, Hindorff LA, Lange E, Walston J, Durda JP, Cushman M, Bis JC, Zeng D, Lin D, Kuller LH, Nickerson DA, Psaty BM, Tracy RP, Reiner AP. Polymorphisms in the C-reactive protein gene are associated with plasma C-reactive protein levels and cardiovascular events. JAMA 2006;296:2703-11.

Shrivastava S, Ridker PM, Glynn RJ, Goldhaber SZ, Moll S, Bounameaux H, Bauer KA, Kessler CM, Cushman M. Plasma D-dimer, factor VIII coagulant activity, low-intensity warfarin and the risk of recurrent venous thromboembolism. J Thromb Haemost 2006;4:1208-14.

Howard G, Prineas R, Moy C, Cushman M, Kellum M, Temple E, Graham A, Howard V. Racial and geographic differences in awareness, treatment and control of hypertension: the Reasons for Geographic And Racial Differences in Stroke (REGARDS) Study. Stroke 2006;37:1171-8.

Zakai NA, Katz R, Hirsch C, Shlipak MG, Chaves P, Newman A, Cushman M. Prospective study of anemia status, hemoglobin and mortality in the elderly: the Cardiovascular Health Study. Arch Intern Med 2005;165:1-7.

Lakoski SG, Cushman M, Palmas W, Blumenthal R, D'Agostino RB Jr, Herrington DM. The relationship between blood pressure and C-reactive protein in the Multi-Ethnic Study of Atherosclerosis. J Am Coll Cardiol 2005;46:1869-74.

Reiner AP, Diehr P, Browner WS, Humphries S, Jenny NS, Cushman M, Tracy RP, Walston J, Lumley T, Newman AB, Kuller LH, Psaty BM. Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: the Cardiovascular Health Study. Atherosclerosis 2005;181:175-83.

Kennedy M, Andreescu ACM, Greenblatt MS, Jiang H, Thomas CA, Chassereau L, Wong C, Durda P, Cushman M. Factor V Leiden, prothrombin 20210A and the risk of venous thrombosis among cancer patients. British J Haematol 2005;128:386-8.

Other Key Publications

Prestwood KM, Unson C, Kulldorff M, Cushman M. The Effect of Different Doses of Micronized 17beta-Estradiol on C-reactive Protein, Interleukin-6 and Lipids in Older Women. J Gerontol A Biol Sci Med Sci 2004;59:M827-32.

Cushman M, Tsai AW, Heckbert SR, White RH, Rosamond WD, Enright P, Folsom AR. Deep vein thrombosis and pulmonary embolism in two cohorts: the Longitudinal Investigation of Thromboembolism Etiology (LITE). Am J Med 2004;117:19-25.

van Korlaar IM, Vossen CY, Rosendaal FR, Bovill EG, Cushman M, Naud S, Kaptein AA. The impact of venous thrombosis on quality of life. Thrombosis Research 2004;114:11-18.

Cushman M, Kuller LH, Prentice R, Rodabough RJ, Psaty BM, Stafford RS, Sidney S, Rosendaal FR, for the Women's Health Initiative Investigators. Estrogen plus progestin and risk of venous thrombosis. JAMA 2004;292:1573-80.

Vossen CY, van Korlaar IM, Cushman M,.Rosendaal FR, Bovill EG. Sensitivity of a questionnaire for data collection on venous thrombosis. Thrombosis Research 2004;114:259-63.

Zakai N, Wright J, Cushman M. Risk factors for venous thrombosis in medical inpatients: validation of a thrombosis risk score. J Thromb Haemost 2004;2:2156-61.

Cushman M, Costantino JP, Bovill EG, Wickerham DL, Buckley L, Roberts JD, Krag DN. Effect of tamoxifen on venous thrombosis risk factors in women without cancer: The Breast Cancer Prevention Trial. British J Haematol 2003;102:109-116.

Cushman M, Folsom AR, Wang L, Aleksic N, Rosamond WD, Tracy RP, Heckbert SH. Fibrin fragment D-dimer and the risk of future venous thrombosis. Blood 2003;101:1243-8.

Ridker PM, Goldhaber SZ, Danielson E, Rosenberg Y, Eby CS, Deitcher SR, Cushman M, Moll S, Kessler CM, Elliott CG, Paulson R, Wong T, Bauer KA, Schwartz BA, Bounameaux H, Glynn RJ, on behalf of the Prevention of Recurrent Venous Thromboembolism (PREVENT) Investigators. Long-Term, Low-Intensity Warfarin for the Prevention of Recurrent Venous Thromboembolism: A Randomized, Double-Blind, Placebo-Controlled Trial. New Engl J Med 2003;348:1425-34.

Abdollahi M, Cushman M, Rosendaal FR. Obesity: risk of venous thrombosis and the interaction with coagulation factors and oral contraceptive use. Thromb Haemost. 2003;89:493-8.

Folsom AR, Cushman M, Heckbert SR, Rosamond WD, Aleksic N. A prospective study of fibrinolytic markers and venous thromboembolism. J Clin Epidemiol 2003;56:598-603.

Manson JE, Hsia J, Johnson KC, Rossouw JE, Assaf AR, Lasser NL, Trevisan M, Black HR, Heckbert SR, Detrano R, Strickland OL, Wong ND, Crouse JR, Stein E, Cushman M, for the WHI Investigators. Estrogen plus progestin and risk of coronary heart disease: final results from the Women's Health Initiative randomized clinical trial. New Engl J Med 2003;349:523-34.

Psaty BM, Cushman M, Rosendaal FR. Simulation of a putative susceptibility risk factor to explain the findings of the Heart and Estrogen/progestin Replacement Study (HERS). GeneScreen 2002:1;169-71.

Folsom AR, Cushman M, Tsai MY, Heckbert SR, Aleksic N. Prospective study of the G20210A polymorphism in the prothrombin gene, plasma prothrombin concentration, and incidence of venous thromboembolism. Am J Hematol 2002;71:285-90.

Tsai AW, Cushman M, Rosamond WD, Heckbert SR, Tracy RP, Aleksic N, Folsom AR. Coagulation factors, inflammation markers, and venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology (LITE). Am J Med 2002;113:636-42.

Cushman M, Costantino JP, Tracy RP, Song K, Buckley L, Roberts JD, Krag DN. Tamoxifen and cardiac risk factors in healthy women: suggestion of an anti-inflammatory effect. Arterioscler Thromb Vasc Biol 2001;21:255-61.

Geffken DF, Cushman M, Burke GL, Polak JF, Sakkinen PA, Tracy RP. The association of physical activity and markers of inflammation in a healthy elderly population. Am J Epidemiol 2001;153:242-50.

Carlson CL, Cushman M, Enright PL, Cauley JA, Newman AB. Hormone replacement therapy is associated with higher FEV1 in elderly women. Am J Respir Crit Care Med 2001;163:423-8.

Cushman M, Booth SL, Possidente CJ, Davidson KW, Sadowski JA, Bovill EG. The association of vitamin K status with warfarin sensitivity at the onset of treatment. Br J Haematol 2001;112:572-7.

Possidente CJ, Howe JG, Cushman M. Evaluation of very low dose subcutaneous vitamin K during postoperative warfarin therapy. Pharmacotherapy 2001;21:295-300.

Barinas-Mitchell E, Cushman M, Meilahn EN, Tracy RP, Kuller LH. Serum levels of C-reactive protein are associated with obesity, weight gain, and hormone replacement therapy in healthy postmenopausal women. Am J Epidemiol 2001;153:1094-101.

Andreescu ACM, Possidente C, Hsieh M, Cushman M. Evaluation of a pharmacy-based surveillance program for heparin-induced thrombocytopenia. Pharmacotherapy 2000;20:974-80.