James Vincent, Ph.D.
Assistant Research Professor, Department of Biology
Director, Bioinformatics Core, Vermont Genetics Network
Research Programs: Genome Stability and Expression; Cancer Prevention & Control
VCC Membership Level: Affiliate Member
Contact Information
120A Marsh Life Science Building
University of Vermont
Burlington, VT 05405
ph: 802-656-3572
f: 802-656-5838
James.Vincent@uvm.edu
Biography
Dr. Vincent earned his Ph.D. in 1999 from The Pennsylvania State University in physical chemistry. He served as a postdoctoral fellow and an information technology specialist at the National Cancer Institute before coming to the University of Vermont in 2007 as the director of the Bioinformatics Core at the Vermont Genetics Network.
Research
Dr. Vincent is currently working with fellow VCC member Dr. Greenblatt on interpretation and classification of gene mutations in cancer. The goal is to develop a predictor for the clinical relevance of mutations in the CDKN2a (p16) and other genes.
Recent Publications
Levitin F, Weiss M, Hahn Y, Stern O, Papke RL, Matusik R, Nandana SR, Ziv R, Pichinuk E, Salame S, Bera T, Vincent J, Lee B, Pastan I, Wreschner DH. PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity. J Biol Chem. 2008 Jun 13;283(24):16928-39.
Onda M, Nagata S, FitzGerald DJ, Beers R, Fisher RJ, Vincent JJ, Lee B, Nakamura M, Hwang J, Kreitman RJ, Hassan R, Pastan I. Characterization of the B cell epitopes associated with a truncated form of Pseudomonas exotoxin (PE38) used to make immunotoxins for the treatment of cancer patients. J Immunol. 2006 Dec 15;177(12):8822-34.
Egland KA, Liu XF, Squires S, Nagata S, Man YG, Bera TK, Onda M, Vincent JJ, Strausberg RL, Lee B, Pastan I. High expression of a cytokeratin-associated protein in many cancers. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5929-34. Epub 2006 Apr 3.
Tai CH, Lee WJ, Vincent JJ, Lee BK. Evaluation of domain prediction in CASP6. Proteins. 2005;61 Suppl 7:183-92.
Vincent JJ, Tai CH, Sathyanarayana BK, Lee BK. Assessment of CASP6 Predictions for New and Nearly New Fold Targets. Proteins. 2005;61 Suppl 7:67-83.
